Risorse
Ricerca scientifica
SIBO: Informazioni Generali
- Italian guidelines for the management of irritable bowel syndrome in children and adolescents : Joint Consensus from the Italian Societies of: Gastroenterology, Hepatology and Pediatric Nutrition (SIGENP), Pediatrics (SIP), Gastroenterology and Endoscopy (SIGE) and Neurogastroenterology and Motility (SINGEM) PMID: 38486305
- Psychological distress in individuals with irritable bowel syndrome: the roles of body image and self-criticism. PMID: 38562654
- Characterization of the Small Bowel Microbiome Reveals Different Profiles in Human Subjects Who Are Overweight or Have Obesity PMID: 38578969
- Functional Abdominal Bloating and Gut Microbiota: An Update PMID: 39203511
- Summary: This 12-study review found that “restoring a balanced microbiome appears to be the most promising solution” via “probiotics, prebiotics, antibiotics such as rifaximin or dietary modifications”, as well as “neuromodulators, and brain-gut behavioral therapies (i.e., cognitive-behavioral therapy)”.
- Small Intestinal Bacterial Overgrowth PMID: 31536241
- Critical appraisal of the SIBO hypothesis and breath testing: A clinical practice update endorsed by the European society of neurogastroenterology and motility (ESNM) and the American neurogastroenterology and motility society (ANMS) PMID: 38798120
- [SIBO, from myth to reality] PMID: 39237384
- [Small intestinal bacterial overgrowth (SIBO) – Therapy, nutrition, microbiome] PMID: 39208859
Cause / Fattori di rischio
Malattie
Farmaci
Interventi chirurgici
- Effects of Probiotic Use on Gastrointestinal Symptoms in the Late Postoperative Period of Bariatric Surgery: A Cross-Over, Randomized, Triple-Blind, Placebo-Controlled Study PMID: 38418752
- Prospective Monitoring of Small Intestinal Bacterial Overgrowth After Gastric Bypass: Clinical, Biological, and Gas Chromatographic Aspects PMID: 38300481
- Blind Loop Syndrome PMID: 36508549
- Modified Rosi-Cahill technique after left extended colectomy for splenic flexure advanced tumors PMID: 39031212
Fisiopatologia
- Small intestinal microbiota: from taxonomic composition to metabolism PMID: 38503579
- Small Intestine Bacterial Overgrowth is associated with increased Campylobacter and epithelial injury in duodenal biopsies of Bangladeshi children. PMID: 38536881
- Fecal Coprococcus, hidden behind abdominal symptoms in patients with small intestinal bacterial overgrowth PMID: 38796441
- Intestinal Methanogen Overgrowth (IMO) Is Associated with Delayed Small Bowel and Colonic Transit Time (TT) on the Wireless Motility Capsule (WMC) PMID: 39068378
- Identification of SIBO Subtypes along with Nutritional Status and Diet as Key Elements of SIBO Therapy PMID: 39000446
- Symptom Profile of Patients With Intestinal Methanogen Overgrowth: A Systematic Review and Meta-analysis PMID: 39147218
- Summary: Review of 19 studies analyzing symptoms present in those with IMO (Methane-SIBO)
- bloating (78%)
- constipation (51%)
- diarrhea (33%)
- abdominal pain (65%)
- nausea (30%)
- flatulence (56%)
- Summary: Review of 19 studies analyzing symptoms present in those with IMO (Methane-SIBO)
Condizioni associate
Bypass gastrico
- Prospective Monitoring of Small Intestinal Bacterial Overgrowth After Gastric Bypass: Clinical, Biological, and Gas Chromatographic Aspects PMID: 38300481
- Effects of Probiotic Use on Gastrointestinal Symptoms in the Late Postoperative Period of Bariatric Surgery: A Cross-Over, Randomized, Triple-Blind, Placebo-Controlled Study PMID: 38418752
Diabete
Epatopatie / malattie del fegato
- Efficacy and Safety of a Probiotic Containing Saccharomyces boulardii CNCM I-745 in the Treatment of Small Intestinal Bacterial Overgrowth in Decompensated Cirrhosis: Randomized, Placebo-Controlled Study PMID: 38337613
- Dysbiosis and nutrition in steatotic liver disease: addressing the unrecognized small intestinal bacterial overgrowth (SIBO) challenge PMID: 38499938
- Small intestinal bacterial overgrowth in obese patients with biopsy-confirmed metabolic dysfunction-associated steatotic liver disease: a cross-sectional study PMID: 38854668
- Impact of small intestinal bacterial overgrowth on systemic inflammation, circulatory and renal function, and liver fibrosis in patients with cirrhosis and ascites PMID: 38779647
- MASLD can cause halitosis by small intestinal bacterial overgrowth PMID: 38764349
Fibrosi Cistica
GERD
H. pylori
IBD (Inflammatory Bowel Disease)
IBS (Irritable Bowel Syndrome)
Insufficienza intestinale (pediatrica)
Ipotiroidismo
Odontoiatria / salute dentale
Parkinson's
- Helicobacter pylori infection and Parkinson’s Disease: etiology, pathogenesis and levodopa bioavailability PMID: 38166953
- A review of the gastrointestinal, olfactory, and skin abnormalities in patients with Parkinson’s disease PMID: 38195133
- Consensus practice recommendations for management of gastrointestinal dysfunction in Parkinson disease PMID: 38729797
- The Gut Microbiota in Parkinson Disease: Interactions with Drugs and Potential for Therapeutic Applications PMID: 38570412
Pediatria
- Factors associated with D-lactic acidosis in pediatric intestinal failure: A case-control study PMID: 38374557
- Assessment of Biochemical, Inflammatory Biomarkers and Ultra-Processed Food Consumption in Children with Small Intestinal Bacterial Overgrowth: A Cross-Sectional Study PMID: 39125359
- Pediatric Chronic Intestinal Failure: Something Moving? PMID: 39275281
Sclerosi sistemica
- Severe small bowel involvement and chronic intestinal pseudo-obstruction in systemic sclerosis (scleroderma): Pathophysiological, diagnostic and therapeutic basis, including parenteral nutrition] PMID: 38388303
- Diffuse Gastrointestinal Motor Compromise in Patients with Scleroderma: Utility of Minimally Invasive Techniques PMID: 37982941
- A multi-national survey to identify clinicians’ perspectives concerning Proton Pump inhibitors in patients with systemic sclerosis PMID: 38430623
Trattamento
Antibiotici
- Antibiotics for Dyspepsia: Hp, SIBO, IMO, or Something Else? PMID: 38363520
- Symptomatic Response to Antibiotics in Patients With Small Intestinal Bacterial Overgrowth: A Systematic Review and Meta-analysis PMID: 38173154
- Amoxicillin Clavulanate PMID: 30844191
- Summary: “the efficacy of amoxicillin-clavulanate in treating SIBO approximates 50%”
- Rifaximin and alternative agents in the management of irritable bowel syndrome: A comprehensive review PMID: 39041415
- Low dose rifaximin combined with N-acetylcysteine is superior to rifaximin alone in a rat model of IBS-D: a randomized trial PMID: 39103611
- Summary: (rat study) “poor solubility [of Rifaximin] may limit its efficacy against microbes in the mucus layer, e.g. Escherichia coli. Here we evaluate adding the mucolytic N-acetylcysteine (NAC) to improve rifaximin efficacy. …combining rifaximin with NAC had significant synergistic effects in reducing E. coli levels.”
Dr. Pimentel and I discuss the “special formulation” of NAC that he used in a recent interview. Watch it Here (NAC discussion is at 1:21 hours, study results at 20:34 min)
- Summary: (rat study) “poor solubility [of Rifaximin] may limit its efficacy against microbes in the mucus layer, e.g. Escherichia coli. Here we evaluate adding the mucolytic N-acetylcysteine (NAC) to improve rifaximin efficacy. …combining rifaximin with NAC had significant synergistic effects in reducing E. coli levels.”
Antibiotici naturali
Dieta
Dieta Elemenare
- Effect, Tolerability, and Safety of Exclusive Palatable Elemental Diet in Patients with
Intestinal Microbial Overgrowth PMID: 40189034
Dieta low FODMAP
- The Role of the FODMAP Diet in IBS PMID: 38337655
- Alterations in gut microbiota caused by major depressive disorder or a low FODMAP diet and where they overlap PMID: 38260072
- Can we predict who will respond to a low-FODMAP diet in irritable bowel syndrome? PMID: 38238032
- Nutrition and Disorders of Gut-Brain Interaction PMID: 38202005
- Effect of fibre fortification of low FODMAP pasta PMID: 38225882
- Efficacy and Findings of a Blinded Randomized Reintroduction Phase for the Low FODMAP Diet in Irritable Bowel Syndrome PMID: 38401741
- Fructan Concentrations in Cooked Cereal Grains as a Nutritional Consideration for Low-FODMAP Diet PMID: 38257195
- Quality characteristics of cereal-based foods enriched with different degree of polymerization inulin: A review PMID: 38431396
- Diet low in fodmaps: fundamentals, evidence and controversies PMID: 38493009
- Exploration of differential responses to FODMAPs and gluten in people with irritable bowel syndrome- a double-blind randomized cross-over challenge study PMID: 38347192
- Fructose malabsorption and fructan malabsorption are associated in patients with irritable bowel syndrome PMID: 38654193
- Effect of the Low Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols (FODMAP) Diet on Control of Pediatric Irritable Bowel Syndrome and Quality of Life Among a Sample of Egyptian Children: A Randomized Controlled Clinical Trial. PMID: 38910620
- The low-FODMAP diet PMID: 38906802
- Changes in Fecal Short-Chain Fatty Acids in IBS Patients and Effects of Different Interventions: A Systematic Review and Meta-Analysis. PMID: 38892659
- Is the Mediterranean Low Fodmap Diet Effective in Managing Irritable Bowel Syndrome Symptoms and Gut Microbiota? An Innovative Research Protocol. PMID: 38892525
- A diet low in fermentable oligo-, di-, monosaccharides and polyols improves abdominal and overall symptoms in persons with all subtypes of irritable bowel syndrome. PMID: 38887150
- Unveiling the dynamics of gut microbial interactions: a review of dietary impact and precision nutrition in gastrointestinal health. PMID: 38873568
- [Gastrointestinal symptoms and dietary intake of patients with irritable bowel syndrome following a low FODMAP diet]. PMID: 38809220
- Causative Factors, Clinical Manifestations, and Therapeutic Strategies for Irritable Bowel Syndrome. PMID: 38779277
- Evolution, adaptation, and new applications of the FODMAP diet. PMID: 38770353
- The efficacy and real-world effectiveness of a diet low in fermentable oligo-, di-, monosaccharides and polyols in irritable bowel syndrome: A systematic review and meta-analysis. PMID: 38754307
- Global research trend and hotspot in the low FODMAP diet: a bibliometric analysis. PMID: 38741213
- Is a Simplified, Less Restrictive Low FODMAP Diet Possible? Results from a Double-Blind, Pilot Randomized Controlled Trial. PMID: 38729393
- All FODMAPs Aren’t Created Equal: Results of a Randomized Reintroduction Trial in Patients With Irritable Bowel Syndrome. PMID: 38729390
- A Multicenter Randomized Controlled Trial of Microbiome-Based Artificial Intelligence-Assisted Personalized Diet vs Low-Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols Diet: A Novel Approach for the Management of Irritable Bowel Syndrome. PMID: 38717025
- Effects of a low FODMAP diet on the symptom management of patients with irritable bowel syndrome: a systematic umbrella review with the meta-analysis of clinical trials. PMID: 38711328
- Nutritional safety and status following a 12-week strict low FODMAP diet in patients with irritable bowel syndrome. PMID: 38689453
- Coffee, Alcohol, and Artificial Sweeteners Have Temporal Associations with Gastrointestinal Symptoms. PMID: 38662159
- Production, modification and degradation of fructans and fructooligosacharides by enzymes originated from plants. PMID: 38649077
- Managing irritable bowel syndrome: balancing diet and pharmacotherapy. PMID: 38643783
- A low FODMAP diet plus traditional dietary advice versus a low-carbohydrate diet versus pharmacological treatment in irritable bowel syndrome (CARIBS): a single-centre, single-blind, randomised controlled trial. PMID: 38643782
- Efficacy of a Low-FODMAP Diet for Coeliac Patients with Persistent IBS-like Symptoms despite a Gluten-Free Diet: A Systematic Review. PMID: 38613127
- Low-FODMAP diet on postprandial distress syndrome type of functional dyspepsia with mixed type of irritable bowel syndrome patient: A case report PMID: 39280305
- A Starch- and Sucrose-Reduced Diet Has Similar Efficiency as Low FODMAP in IBS-A Randomized Non-Inferiority Study PMID: 39275354
- Relationship between Markers of Gut Barrier Function and Erythrocyte Membrane PUFAs in Diarrhea-Predominant IBS Patients Undergoing a Low-FODMAP Diet PMID: 39203842
- Microbiome-driven IBS metabotypes influence response to the low FODMAP diet: insights from the faecal volatome PMID: 39173527
- Patients’ experiences of dietary changes during a structured dietary intervention for irritable bowel syndrome PMID: 39138906
- Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Clinical Trials PMID: 39110917
- DOMINO trial post hoc analysis: evaluation of the diet effects on symptoms in IBS subtypes PMID: 39086991
- Predictors of response to a dietary intervention in patients with irritable bowel syndrome PMID: 39029788
- Sourdough Bread Quality: Facts and Factors PMID: 38998638
- Predicting Response to Low Fermentable Oligo-, Di-, Mono-saccharides, and Polyols Diet in Patients With Abdominal Bloating Using Hydrogen Methane Breath Test: Is a Spot Sample Enough? PMID: 38972871
Fecal Microbiota Transplantation (FMT)
Probiotici
- Do Herbal Supplements and Probiotics Complement Antibiotics and Diet in the Management of SIBO? A Randomized Clinical Trial PMID: 38613116
- Effects of Probiotic Use on Gastrointestinal Symptoms in the Late Postoperative Period of Bariatric Surgery: A Cross-Over, Randomized, Triple-Blind, Placebo-Controlled Study PMID: 38418752
- Probiotics and Prebiotics in Subclinical Hypothyroidism of Pregnancy with Small Intestinal Bacterial Overgrowth PMID: 37032411
Procinetici
- Efficacy and Safety of a Probiotic Containing Saccharomyces boulardii CNCM I-745 in the Treatment of Small Intestinal Bacterial Overgrowth in Decompensated Cirrhosis: Randomized, Placebo-Controlled Study PMID: 38337613
- Clinical outcomes before and after prucalopride treatment: an observational study in patients with chronic idiopathic constipation in the USA PMID: 38357940
- Safety and Effectiveness of Prucalopride in Children with Functional Constipation with and without Upper Symptoms PMID: 38175354
- Effect of Iberogast (STW5) on tolerance to colonic gas in patients with irritable bowel syndrome: A randomized, double-blind, placebo control clinical trial PMID: 38361151
- 5-HT4 receptor agonists treatment reduces tau pathology and behavioral deficit in the PS19 mouse model of tauopathy PMID: 38638303
- Association between a selective 5-HT4 receptor agonist and incidence of major depressive disorder: emulated target trial PMID: 39109752
- Summary: “Treatment with prucalopride was associated with significantly lower incidence of depression … Significantly lower risks of all mood disorders and psychosis were also observed. … These findings support preclinical data and suggest a role for 5-HT4R agonists [prucalopride] as novel agents in the prevention of major depression.”
- Gastroparesis treatment options metoclopramide and prucalopride: analysis of the FDA Adverse Event Reporting System (FAERS) database PMID: 38995209
- Summary: “Analysis of 865 reports [of adverse events] on prucalopride revealed
- headache (n = 120, 13.9%)
- diarrhea (n = 116, 13.4%)
- abdominal pain (n = 100, 11.6%)
- dystonia (n=22, 2.5%)”
- Summary: “Analysis of 865 reports [of adverse events] on prucalopride revealed
- Prokinetic effect of erythromycin in the management of gastroparesis in critically ill patients-our experience and literature review PMID: 39314225
Trimebutina maleato / Debridat
Tests
- Gastric, small bowel and colonic motility and breath-testing /doi.10.1016/j.mpmed.2024.01.004
- Critical appraisal of the SIBO hypothesis and breath testing: A clinical practice update endorsed by the European society of neurogastroenterology and motility (ESNM) and the American neurogastroenterology and motility society (ANMS) PMID: 38798120
- Small Intestinal Bacterial Overgrowth (SIBO), a clinically overdiagnosed entity? PMID: 38719183
- Glucose breath test for the detection of small intestine bacterial overgrowth: Impact of diet prior to the test PMID: 38606691
- Capsules for the Diagnosis and Treatment of Gastrointestinal Motility Disorders- A Game Changer PMID: 38630422
- Detection capacity of small intestine bacterial or methanogen overgrowth by lactose and fructose breath testing in the adult population PMID: 39252801
- Validation of a Hand-Held Point-of-Care Device to Measure Breath Hydrogen and Its Utility in Detecting Response to Antibiotic Treatment PMID: 39127844
- Summary: This study compared FoodMarble AIRE® to existing mail-in kits in patients suspected to have SIBO.
Results: “Substantial agreement was demonstrated between AIRE and the mail-in kits for the performance of lactulose hydrogen breath tests.”
- Summary: This study compared FoodMarble AIRE® to existing mail-in kits in patients suspected to have SIBO.
Metano
Tiroide
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